MILESTONE: Vaccine Number 3!

Poor Rilley, losing more of his fur to
make way for more injections!

Rilley has now reached another milestone. He received his third vaccine today...he is now half way through the bi-weekly treatments! The nice thing is, given that he doesn't mind going to the vet and obviously trusts Dr. Ewing, he didn't even flinch when he was given the injections. While his fur is growing back nicely on the top of his head, Dr. Ewing noted that the areas on the back of his neck, where the injection sites are, has been slow to regrow. She figures that it may be a result on the vaccine/immune system's effects to the immediate area. Now, to add to his "fur-challengedness", Dr. Ewing had to shave some more of his original fur further down the back of his neck! This was necessary to make room for the injections as we cannot reuse prior injection sites.

Rilley receiving the second of two injections
during his third vaccine treatment.

When we were in Minneapolis, Dr. Pluhar had mentioned to us that the first couple of vaccine treatments should be fairly uneventful, however after this particular injection Rilley may experience some of his pre-surgery symptoms. These could even include seizures. It isn't guaranteed that he will experience this, but it isn't uncommon. As long as any seizure activity remains fairly minor (not lasting for long periods) we shouldn't be too concerned and simply help him through it. Hopefully this isn't something that Rilley will run in to.  One extraordinary thing happened today. Rilley's vaccine shipment made it all the way from Minneapolis in less than 24 hours and without any intervention on this end! It was even delivered directly to Dr. Ewing's office without Sara having to pick it up from the FedEx facility at Pearson International!

All in all, for a "vaccine-day" it went very smoothly. He was all done by 12:30pm leaving us time to do some Christmas shopping! We leave you with a shot of Rilley's latest loss of fur....

Rilley's latest bald spot.

Changes to Rilley's blog

New features have been added to the blog.

As you may have noticed, some changes have been made to the layout of the blog.  We've added a listing of the 10 most popular posts to the left column and a sign in box to the right column.  This can make it easier for you to follow new posts to the blog.  Also, if you scroll to the bottom of the page we've added a collection of links to sites that are related to Rilley's story (these will be updated as necessary).  We hope that you'll find these additions useful and informative.

Rilley is still doing well and appreciates everyone's interest in his story.  He is due for his third vaccine treatment this Thursday (Dec. 23) and we'll post an update then.

Physical Signs of the Vaccine at Work

There is now some physical evidence that the vaccine seems to be doing its job.  The vaccine is comprised of two main components.  Irradiated tumour cells, which were harvested from the tumour removed during Rilley's craniotomy and immune activators.  The irradiated tumour cells are dead cells which cannot cause any recurrence of the cancer.

The vaccine is injected intradermally (between skin layers) in two sites at the back of Rilley's neck.  Each site receives a mere 0.5cc of vaccine and the injections are intended to introduce the cancer cells to his body in order to force his immune system to seek out and destroy them.

Our daughters noticed a red area on the back of his neck.  When we had a look we noticed that Rilley's skin had turned red at one of the sites of his initial vaccine injections and his skin appeared to be breaking open.

You will notice on the right side a red area on the skin.
If you click on the image to enlarge it, you will get a better view.

Obviously, we were concerned so we sent photographs off to Drs. Ohlfest and Pluhar back at the University of Minnesota.  Dr. Ohlfest said that it was most likely a result of Rilley's body killing the skin cells that were infiltrated by the injected tumour cells...a very good sign that the vaccine seems to be working.  Basically, his body is learning how to kill cancer cells, or more accurately, any cells that are part of a meningioma.  Dr. Ohlfest actually summed it up quite well when he wrote to us saying that "this is very bad news for any tumour cells left behind after surgery".  Yes, Rilley's building his own army to seek and destory the enemy that was in his head!

So while this seemed at first to be a possible negative reaction to the vaccine or possibly a skin infection, it turned out to be a very good sign.  It's amazing what you learn, especially when you have two brilliant doctors who are so willing to share their knowledge and don't hesitate to answer your questions!  (No matter how many you may have!)

Rilley's fur is on its way back!

One thing we noticed this past weekend is that Rilley's fur is coming back with a fur-y!  (Pun intended.)  If you were to look at him face on, you would be hard pressed to tell that anything had happened.  Below is a comparison of two photos taken exactly three weeks apart.

Rilley's fur, then (three weeks ago) and now!

The one thing we had been wondering was whether or not the white stripe on his face would grow back. When he had been shaved, you could see the pigmentation in his skin which matched his fur colour for those areas, but it looked quite dark up the middle of his face.  However, as you can tell this distinctive mark of his is back!

Other news from this weekend is that he did not seem himself.  As you may have figured from our last post, Rilley had his second round of vaccine injections on Thursday.  One difference about this round was that he really seemed to be under the weather on Saturday.  From reading this blog, you may have figured out that he is very food motivated we knew something was not right when Sara sat on the sofa with a snack, and all Rilley could muster was to raise his head and have a look, as opposed to getting right in her face demanding some of the food!  After consulting with Dr. Ohlfest, it turns out that he may very well have had a low grade fever and may seem sluggish for a few days.  He explained that this is normal as long as it doesn't last for more than a couple of days.  We also noted that his injection sites felt a bit warm.  Apparently this is an indication that more of his immune system is recognizing and working on the tumour cells, which in turn is a good sign that Rilley's body is reacting positively to the vaccine.  However, we are happy to report that tonight he seems to have bounced back quite quickly.

Lastly, thanks to everyone's kind interest in Rilley's story, as of this writing our little blog has had 2016 visits since we started it in late October.  A large part of that is due to the spike in traffic as a result of Rilley's story airing on Daily Planet as well as the front page article written by Lisa Tallyn in the November 30th edition of the Georgetown Independent.

Rilley's 2nd Vaccination - More Shipping Frustrations!

It has been two weeks since Rilley's last vaccination and the major headache getting that one through customs.  Today he had an appointment for his second of six rounds and you'd think that everything would now be in order and the shipment would happen smoothly.  Well, guess again and this time I can't even say it was the government's fault.  From what I can gather, and hopefully it is as factual as it can get, it seems that someone at the courier company took it upon themselves to decide for Canada Custom's what they would or wouldn't do.  Instead of this person allowing the Canadian Border Services Agency to decide for themselves, they refused to pass the package onto the people responsible for what comes into the country!

The precious package!
Styrofoam container, dry ice and a tiny, tiny vial containing the vaccine.

The shipment had been held for clearance in the courier's facility in Mississauga since early this morning and it was finally released to us just before 4pm!  On top of all of that, they made us come and get it as they didn't want to touch the package!  Apparently they read that it contained irradiated cancer cells and thought that they'd get cancer from touching it!  Now I may not be a doctor, but the last time I checked cancer was not contagious and I know that anything that has been irradiated is most definitely dead!  Come on people, use some common sense!  Not to mention that Health Canada provided a "No Objection Letter" stating that they had no reason to stop the package from entering the country and said letter was attached directly to the outside of the package!

The "No Objection Letter" provided by Health Canada securely affixed to the side of the shipping contianer.  Can you believe the courier claimed it wasn't with the package?

I think you can understand how frustrated we are!  Our caring Vet, Dr. Stephanie Ewing, neurosurgeon Dr. Pluhar as well as lab staff at the University of Minnesota had to take time out of their busy schedules once again to deal with what should be a simple process.

The priceless cargo.  Placed next to a car key to give you a sense of how little vaccine is actually shipped.  The vial is only about 1/3 full.

MILESTONE: One month since surgery

Rilley's fur is slowly beginning it's own journey back to his head!

This weekend has marked one month since Rilley underwent the craniotomy to begin his tumour free life!  He is doing extremely well and the Great Canadian Bald Beagle is beginning to show serious signs of regaining his fur.  The best news is that he has now been seizure free for over four weeks.  He is doing so well that he can now be left for a few hours on his own.  We just need to make sure that there is no food out as he is much more active and will get things off the counter once again!  (To most people, that may be a sign of poor behaviour, but no matter how annoying it may be, to us it is a sign that he is getting back to his old self.)

This coming week, Rilley will be receiving the second of his six rounds of vaccines.  We are hoping that the shipment will be much smoother this time around and actually make it to Dr. Ewing's office without any intervention!

We've noticed the increased traffic to the blog since the television and local newspaper stories from early in the week.  As of this writing, the blog has had 1853 visits!  We just want to thank everyone for taking such an interest in Rilley's story and hope you will continue.

UPDATED: Daily Planet show now online!

UPDATED!
If you missed Rilley's appearance on Daily Planet, go to the show's webpage to see it online.

There is a new link to see Rilley's story where it will be available for a long time:

http://watch.discoverychannel.ca/clip383637#clip383637

I would like to thank those who maintain the http://www.discoverychannel.ca/ website for creating this special link for me.  In particular, Heather Mahmood who made it happen.

The original link I posted in this space pointed to the latest online episode which is changed everyday.  However, I would like to leave the link to that available as I believe the show is worth watching, no matter what stories are presented.

The direct link to Daily Planet's page on the Discovery Channel Canada website is: http://www.discoverychannel.ca/Showpage.aspx?sid=13287